12/7/2023 0 Comments Berberine diabetes infographicWhile metabolic effectors bear partial redundancy with polyphenols and metformin (e.g. Diabetes, metabolic syndrome and dyslipidemia have since comprised the predominant focus of clinical research, with the totality of evidence supporting insulin sensitizing and cholesterol-reducing efficacy at doses of 500-1500 mg/day as berberine hydrochloride (Zeng et al, 2003 Kong, et al, 2004 Zhang et al, 2008 Zhang et al, 2010 Dong et al, 2012 Wei, et al, 2012 Perez-Rubio et al, 2013 Lan et al, 2015 Yan et al, 2015).Īn eclectic repertoire of protein interactions, genomic signatures and gut microbial shifts has emanated from the preclinical literature, collectively suggesting a mechanistic departure from all other dietary ingredients. Lipid-lowering effects were later demonstrated and confirmed in multiple human intervention trials (Kong et al, 2004). In 1998, berberine was reported to ameliorate hyperglycemia in diabetic patients undergoing treatment for diarrhea (Ni et al, 1988). Multifarious actions in the host intestine include remediation of mucosal damage and anti-inflammatory effects, which are thought to contribute to its utility in chronic, non-infectious conditions such as irritable bowel syndrome and inflammatory bowel disease (Chen et al, 2015 Habtermariam, 2016). Accordingly, berberine-containing plants have an extensive history in Ayurvedic and Chinese medicine, as antibacterial, antifungal and antidiarrheal agents, with medicinal use dating back over 2,500 years (Birdsall et al, 1997 Domandia et al, 2008). pylori, Shigella, Vibrio, and Cryptococci. Through antiproliferative and anti-adhesive actions, berberine inhibits a wide range of microbial pathogens including Staphylococci, Streptococci, Salmonella, Clostridium, H. Berberine is a quaternary ammonium salt belonging to the protoberberine subclass of benzylisoquinoline alkaloids, distributed in the roots, rhizomes, and stems of over 500 plant species indigenous to Asia and North America, including the medicinal species Hydrastis canadensis (goldenseal), Coptis chinensis (Coptis or goldenthread), Berberis aquifolium (Oregon grape), and Berberis vulgaris (barberry) (Kumar et al, 2015 Singh and Sharma, 2018).
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